STROKE RESEARCH STUDIES

The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Study (CREST-2)

The purpose of CREST-2 is to find the best way to prevent strokes. This study is for people who have narrowing of their carotid artery, without stroke warning signs caused by that artery. CREST-2 is designed to compare three different methods of stroke prevention to find the safest and most effective treatment. The stroke prevention methods include intensive medical management alone compared to intensive medical management in combination with a procedure to reopen the carotid artery in your neck (called revascularization) for treatment of plaque buildup. The two procedures available in this trial are carotid endarterectomy and carotid stenting. All study participates will receive intensive medical management to help control their risk factors for stroke.

Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST)

The purpose of the CREST study is to compare the results of treating blockages in the carotid arteries with either carotid artery surgery (Endarteroctomy) or carotid artery stenting.  Patients enrolled in CREST were assigned by chance to one of the treatments.  We compared the risks and benefits of the two treatments in preventing stroke.  Both of the treatments were selected because they are often used by doctors when treating patients who are at risk of stroke and because it was uncertain which treatment was better.  The study is currently not enrolling. Patients are still being followed with a hospital visit for a carotid ultrasound as well as labs. The patient also receives a phone call from the research team once a year.

Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy (CANOPY)

The purpose of this study is to evaluate the continued safety and effectiveness of the Acculink Carotid Artery Stent System, used in conjunction with the Accunet Embolic Protection Device during commercial use in the USA. The study is being conducted solely to collect information on medical condition related to the stent(s) patients have received. The study is currently not enrolling. Patient follow-up happens once a year for 3 years

Insulin Resistance Intervention after Stroke (IRIS) Trial

IRIS is testing the effectiveness of lowering insulin resistance with pioglitazone, compared with placebo, for prevention of recurrent stroke and myocardial infarction in non-diabetic patients with cerebrovascular disease and insulin resistance. The study is currently not enrolling (in follow-up phase). Patients have an annual clinic visit in addition to two follow-up phone visits a year.

ACTION-2: 101SK202

A multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group, Dose-Ranging Study to Evaluate the Safety and Efficacy of Intravenous Natalizumab (BG00002) in Acute Ischemic Stroke.

Principal Investigator

Irfan Altafullah, M.D.

Research Contacts

Tristan, Research Coordinator – 763-302-4026